She is best known for her role as Peggy Bundy, Al's sarcastic, lazy, bon bon-eating wife, on Married...
with Children and for her role as Gemma Teller Morrow on the FX series Sons of Anarchy.
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In 1998, Matt Groening cast her as the purple-haired mutant spaceship captain, Leela, in his science-fiction animated comedy Futurama.
Sagal is also known for voicing the character Leela on the animated science-fiction series Futurama from 1999 to 2003, then from 2008 to 2013, as well as for starring on the show 8 Simple Rules in the role of Cate Hennessy.
In the latter role, she worked with John Ritter until his death, leading to Sagal's taking over as the series lead for the remainder of the show's run.