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The sympathomimetic properties of amphetamine were unknown until 1927, when pioneer psychopharmacologist Gordon Alles independently resynthesized it and tested it on himself while searching for an artificial replacement for ephedrine.A thriving black market in pep pills among long-haul truck drivers in the 1950s and 1960s, linked to long drive times and intense competitive pressures within the industry, contributed to federal efforts by the late 1960s to curtail non-medical use of the substance.

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Up to a quarter of college students use Adderall to help them focus on their studies instead of its intended purpose of helping people with ADHD.

This use sometimes continues after the student graduates college due to its addictive properties.

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