List of antihistamine sedating non

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Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil.

Once released, the histamine can react with local or widespread tissues through histamine receptors.

First-generation antihistamines include diphenhydramine (Benadryl), carbinoxamine (Clistin), clemastine (Tavist), chlorpheniramine (Chlor-Trimeton), and brompheniramine (Dimetane).This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information.To find the most current information, please enter your topic of interest into our search box.The most common adverse effect is sedation; this "side-effect" is utilized in many OTC sleeping-aid preparations.

Additional administration of epinephrine, often in the form of an autoinjector (Epi-pen), is required by people with such hypersensitivities.H-antihistamines can be administered topically (through the skin, nose, or eyes) or systemically, based on the nature of the allergic condition.

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