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They also activate the acid-producing, parietal cells of the stomach lining.Histamine dilates blood vessels and acts with prostaglandins, PGE2 and PGI2, to produce the early swelling, redness and heat of an inflammatory response.

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H1 receptors tend to produce the symptoms already listed and activate allergic reactions.H2 receptors tend to act as negative feedback receptors and turn the allergic reaction off.

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