She met Brian Austin Green on the show and the two had a baby together named Kassius Lijah Marcil-Green born on March 30, 2002.
In the fall of 2002 she made her long-awaited return to General Hospital reprising her role as Brenda Barrett, garnering her a Daytime Emmy Award for "Outstanding Supporting Actress" in 2003.
She made her feature film debut in The Rock opposite Nicolas Cage and starred in a made-for-television movie, To Love, Honor and Deceive, in 1996.
She stayed with General Hospital until 1998 and then left to join the cast of Beverly Hills, 90210 as Gina Kincaid, a former ice skater replacing Tiffani Thiessen as the show's vixen.
Although she did make a guest appearance in April 2013 to commemorate the show's 50th anniversary.
Vanessa later joined the cast of the NBC drama Las Vegas as Sam Marquez, a casino host where she remained on the show for five seasons until 2008.
That same year she became the host of Lifetime's reality show Blush: The Search for America's Greatest Makeup Artist as well as making a three episode guest appearance on the NBC show Lipstick Jungle.